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C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it.[1][2] The gene is also known as Islet-Brain-2 (IB2).

This protein is highly expressed in the brain and is almost always deleted in Phelan-McDermid syndrome (PMS). MAPK8IP2 appears to regulate the ratio of AMPA receptors to NMDA receptors at glutamate synapses,[3] and thus may be an important contributor to the intellectual dysfunction and related neurological manifestations characteristic of PMS.

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.[2]

Interactions[edit]

MAPK8IP2 has been shown to interact with MAP3K10,[1]Mitogen-activated protein kinase 9,[1]LRP2,[4][5]LRP1,[4]MAPK8IP3,[6]MAP3K12,[1]MAPK8IP1,[1]MAP2K7[1][7] and MAP3K11.[1]

References[edit]

  1. ^ a b c d e f g Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (February 2000). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol Cell Biol 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.  CS1 maint: Multiple names: authors list (link)
  2. ^ a b "Entrez Gene: MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2". 
  3. ^ Giza J, et al. (2010). "Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.". J Neurosci. 30 (44): 14805–16. doi:10.1523/JNEUROSCI.1161-10.2010. PMC 3200367. PMID 21048139. 
  4. ^ a b Gotthardt, M; Trommsdorff M; Nevitt M F; Shelton J; Richardson J A; Stockinger W; Nimpf J; Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. (UNITED STATES) 275 (33): 25616–24. doi:10.1074/jbc.M000955200. ISSN 0021-9258. PMID 10827173. 
  5. ^ Petersen, Helle Heibroch; Hilpert Jan; Militz Daniel; Zandler Valerie; Jacobsen Christian; Roebroek Anton J M; Willnow Thomas E (February 2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. (England) 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. ISSN 0021-9533. PMID 12508107. 
  6. ^ Kelkar, N; Gupta S; Dickens M; Davis R J (February 2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. ISSN 0270-7306. PMC 85220. PMID 10629060. 
  7. ^ Negri, S; Oberson A; Steinmann M; Sauser C; Nicod P; Waeber G; Schorderet D F; Bonny C (March 2000). "cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein". Genomics (UNITED STATES) 64 (3): 324–30. doi:10.1006/geno.2000.6129. ISSN 0888-7543. PMID 10756100. 

Further reading[edit]

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  CS1 maint: Multiple names: authors list (link)
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.  CS1 maint: Multiple names: authors list (link)
  • Negri S, Oberson A, Steinmann M, et al. (2000). "cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein". Genomics 64 (3): 324–30. doi:10.1006/geno.2000.6129. PMID 10756100. 
  • Gotthardt M, Trommsdorff M, Nevitt MF, et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173. 
  • Schoorlemmer J, Goldfarb M (2001). "Fibroblast growth factor homologous factors are intracellular signaling proteins". Curr. Biol. 11 (10): 793–7. doi:10.1016/S0960-9822(01)00232-9. PMC 3216481. PMID 11378392. 
  • Taru H, Kirino Y, Suzuki T (2002). "Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism". J. Biol. Chem. 277 (30): 27567–74. doi:10.1074/jbc.M203713200. PMID 12023290.  CS1 maint: Multiple names: authors list (link)
  • Buchsbaum RJ, Connolly BA, Feig LA (2002). "Interaction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 Mitogen-Activated Protein Kinase Cascade". Mol. Cell. Biol. 22 (12): 4073–85. doi:10.1128/MCB.22.12.4073-4085.2002. PMC 133864. PMID 12024021.  CS1 maint: Multiple names: authors list (link)
  • Schoorlemmer J, Goldfarb M (2003). "Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase". J. Biol. Chem. 277 (51): 49111–9. doi:10.1074/jbc.M205520200. PMID 12244047. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ (2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. 278 (12): 10731–6. doi:10.1074/jbc.M207324200. PMID 12524447.  CS1 maint: Multiple names: authors list (link)
  • Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Kristensen O, Guenat S, Dar I, et al. (2006). "A unique set of SH3–SH3 interactions controls IB1 homodimerization". EMBO J. 25 (4): 785–97. doi:10.1038/sj.emboj.7600982. PMC 1383563. PMID 16456539. 


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