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Deaths from pancreatic ductal adenocarcinoma, also known as pancreatic cancer, rank fourth among cancer-related deaths in the United States, yet the causes of pancreatic cancer remain unknown. This review article summarizes recent progress in the understanding and management of pancreatic cancer.

Dr. Hidalgo reports receiving grant support from Roche and Daichi; being the principal investigator and receiving grant support for clinical studies of nanoparticle albumin-bound paclitaxel from American Biosciences, of erlotinib from Roche, of AGS-1C4D4 from Agensys, and of MORAb-009 from Eisai; and receiving consulting fees from American Biosciences, OSI–Genentech, Merck, and Agensys.

No other potential conflict of interest relevant to this article was reported.

This article (10.1056/NEJMra0901557) was updated on July 14, 2010, at NEJM.org.

I thank Wells Messersmith and Anirban Maitra for critical comments on an earlier version of the manuscript and Sofia Perea for editorial assistance.

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